Concomitant usage of benzodiazepines and opioids may cause profound sedation, respiratory depression, coma, and Loss of life. Reserve concomitant prescribing of such drugs in patients for whom alternative treatment alternatives are insufficient.
The solution label for diazepam recommends that diazepam really should not be used when breastfeeding. Speak to your healthcare service provider to determine if the benefit of making use of diazepam on your ailment outweighs the probable pitfalls. [eight]
Seizures. Taking diazepam tablets with other medicines used to treat epilepsy might cause a rise in the amount or severity of grand mal seizures. •
Actual physical dependence and withdrawal reactions. Diazepam tablets could cause physical dependence and withdrawal reactions.
Along with its required effects, a medicine could lead to some undesirable effects. Despite the fact that not every one of these side effects may well come about, if they do happen they may need healthcare notice.
Individuals who have a history of, or presently undergo from the next psychological problems should seek the advice of their healthcare provider before taking diazepam:
Diazepam and other benzodiazepines act by improving the effects of gamma-aminobutyric acid (GABA) inside the brain. GABA is actually a neurotransmitter (a chemical that nerve cells use to communicate with Every single other) that inhibits action inside diazepam and alcohol the brain.
Diazepam and its metabolites are excreted mainly inside the urine, predominantly as their glucuronide conjugates. The clearance of diazepam is 20 to 30 mL/min in young adults. Diazepam accumulates upon various dosing and There exists some evidence that the terminal elimination half-life is a little prolonged.
Will not generate or operate significant machinery until eventually you know how taking diazepam tablets with opioids have an affect on you. •
When you skip a dose of diazepam, it's best to await another a single rather than double up. Doubling dosage will not strengthen symptoms faster and can in truth worsen your problem.
Suicidal feelings or actions may be caused by matters other than medicines. In case you have suicidal thoughts or actions, your healthcare service provider may well check for other causes.
For anyone who is prescribed diazepam for much more than four weeks, your dose might be lessened progressively any time you end taking it to prevent withdrawal symptoms.
Restless leg syndrome (RLS) can be a common reason for painful legs that usually eases with motion, and becomes worse and even more apparent at rest.
When physical dependence to benzodiazepines has produced, termination of treatment will be accompanied by withdrawal symptoms. The chance is much more pronounced in patients on long-term therapy.